236: Chapter 236 The Perfect Closed Loop!

"Oh."

Xia Laixi saw Zhao Fusu like this and couldn't help but ask, "His Majesty the Head of State, do you also know how to treat illnesses?"

"I have heard of this disease."

Zhao Fusu said, "Do you believe that worms can grow inside the lungs?"

"This!"

Xia Laixi was startled.

He couldn't help but exclaim, "Worms growing in the lungs!"

"Yes."

Zhao Fusu nodded.

Based on his judgment, Lu Jia and Tian Ju did not have infectious pneumonia, but rather pulmonary hydatid disease.

Just as Zhao Fusu said, worms were growing in their lungs.

This pulmonary hydatid disease, also known as pulmonary echinococcosis, is a zoonotic parasitic disease caused by the larvae of the Echinococcus tapeworm parasitizing the lungs.

The definitive hosts of Echinococcus granulosus are mainly carnivores such as dogs and wolves, while the intermediate hosts are mainly herbivores such as sheep, cattle, and horses. Humans become infected by accidentally ingesting food or water contaminated with the eggs.

The eggs hatch into oncospheres in the human digestive tract. These oncospheres penetrate the intestinal wall to enter the blood circulation and reach the lungs through the bloodstream, where they develop into hydatid cysts, forming pulmonary hydatid cysts.

Zhao Fusu knew about this disease because one of his neighbors had a dog but didn't provide proper deworming protection. The neighbor slept with the dog every day, leading to a severe case of pulmonary hydatid disease that required surgery to remove the parts of the lung containing the cysts.

"Then how should this disease be treated!"

Xia Laixi stared at Zhao Fusu with burning eyes.

For this disease, their School of Medicine had no effective methods. Generally, they used herbs with effects such as dispelling dampness, resolving phlegm, softening hardness, and dissipating masses to help alleviate symptoms and improve the patient's physical condition. For example, formulas composed of medicinal materials like Salvia miltiorrhiza, Astragalus, and Artemisia annua.

If this disease truly was as His Majesty the Head of State said—worms moving into the lungs—then formulas composed of these medicinal materials could only improve the patient's constitution and could not kill the parasites.

This was indeed the case. pulmonary hydatid cysts generally grow progressively, and "self-healing" is extremely rare. The vast majority will eventually rupture due to increased pressure within the cyst, leading to serious complications.

Zhao Fusu said, "The parasites that have entered the lungs must be killed for the patient to be cured!"

Lu Jia, Tian Ju, Jin Tu, Qing Ying, and Lie Yun had only just fallen ill. It was still a mild infection. Using anthelmintic drugs should be able to kill the Echinococcus granulosus that had entered their lungs.

Seeing that Zhao Fusu really had a way to treat this pulmonary hydatid disease, Xia Laixi became increasingly excited.

It wasn't that he hadn't treated patients with pulmonary hydatid disease before.

The formulas he prescribed had failed to save the patients' lives.

He could only watch helplessly as patients died before him and their relatives wept until they were in tears, while he, as a physician, was powerless.

He had tried to formulate prescriptions to cure pulmonary hydatid disease, but no matter how Xia Laixi searched through the medical books passed down, he could not find a method to treat it.

Now, seeing that Zhao Fusu had a method to treat pulmonary hydatid disease, how could he not be agitated?

"Does His Majesty the Head of State have a formula for treating pulmonary hydatid disease?"

Xia Laixi asked with a face full of anticipation.

"No!"

Zhao Fusu spread his hands and said.

He remembered that there were specific drugs for pulmonary hydatid disease, namely albendazole and albendazole.

However, in ancient times, he had neither albendazole nor albendazole.

"Sigh!"

Hearing this, Xia Laixi's face was filled with disappointment.

"We can make it ourselves."

Zhao Fusu smiled.

"Oh!"

Xia Laixi was startled and looked at Zhao Fusu.

"Yes."

Zhao Fusu nodded.

"System, I want the manufacturing process for albendazole or albendazole."

After speaking to the system, Zhao Fusu began his daily check-in.

"Congratulations to the host for obtaining the manufacturing process for albendazole."

The corners of Zhao Fusu's mouth curled up; this made things easy.

He began to study albendazole.

It can directly inhibit the parasite's intake of glucose, preventing it from growing and reproducing.

The adverse reactions of albendazole are relatively few; occasionally, mild gastrointestinal discomfort, headache, and fatigue may occur. It is not suitable for pregnant women and children under two years old.

Lu Jia and Tian Ju hadn't been on the grassland for long, so they should only have mild pulmonary hydatid disease. Using albendazole should be able to directly kill the larvae of the Echinococcus tapeworm in their lungs!

Zhao Fusu looked at the specific synthesis method for albendazole.

The steps were very complex, involving various reactions; they could not be understood without a certain amount of chemical knowledge and patience.

Roughly, 4-chloro-3-nitrobenzoic acid is first chlorinated with thionyl chloride and then condensed with benzene under the catalysis of aluminum trichloride.

Next, the condensation product is aminated and reduced to obtain 3,4-diaminobenzophenone.

Then, 3,4-diaminobenzophenone undergoes a cyclization reaction to produce albendazole.

It didn't look simple, and in reality, it was even less so.

These terms—if one wasn't in pharmaceuticals, they wouldn't have even heard of them.

Zhao Fusu continued to flip through the chemical engineering books he had obtained from check-ins.

He needed to consult a vast amount of information and understand various reactions before he could produce it.

After all, whether it was 4-chloro-3-nitrobenzoic acid, chlorination with thionyl chloride, or aluminum trichloride, they all involved numerous reactions.

Fortunately, hard work pays off. Through Zhao Fusu's tireless efforts, he finally found all the necessary reactions.

Zhao Fusu recorded all these reactions and then sent people to find the raw materials required for them.

Once the raw materials were collected, he put on gloves and protective clothing made of synthetic rubber to extract and react the raw materials to synthesize albendazole.

After Zhao Fusu lost a large handful of hair, he looked at the odorless white crystalline powder he had synthesized with a face full of excitement.

Synthesizing this thing really wasn't easy!

Looking at the albendazole, the corners of Zhao Fusu's mouth curled up.

In the future, there would be one more item to trade with the Xiongnu Tribes.

Besides being used to kill the larvae of Echinococcus tapeworms, this albendazole could also treat ascariasis, enterobiasis, hookworm infection, trichuriasis, and strongyloidiasis.

Not only could the Xiongnu people use it, but the people of Great Qin could also use it.

Zhao Fusu decided to manufacture albendazole in large quantities.

The profit from pharmaceutical manufacturing was not low!

Zhao Fusu rubbed his chin.

He could also make stomach medicine to treat gastric diseases.

In terms of diet, combine hot pot with ice cream.

Eating hot pot with ice cream—the alternation of hot and cold makes people prone to stomach problems. Then, selling stomach medicine would form a perfect closed loop!

It wasn't that he was wicked; he was just following a proven example.

Zhao Fusu sent people to compress the synthesized albendazole powder into tablets and then packed them into medicine bottles.

He instructed the medicine deliverer, "Have Lu Jia and Tian Ju take it three times a day, two tablets each time."

"Understood!"

The knight galloped at full speed toward the Qinglan Grassland.